The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form

Squalene monooxygenase (SM, also known as squalene epoxidase) is a rate-limiting enzyme of cholesterol synthesis that converts squalene to monooxidosqualene and is oncogenic in numerous cancer types. SM is subject to feedback regulation via cholesterol-induced proteasomal degradation, which depends...

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Detalles Bibliográficos
Autores principales: Coates, Hudson W., Capell-Hattam, Isabelle M., Brown, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166775/
https://www.ncbi.nlm.nih.gov/pubmed/33933449
http://dx.doi.org/10.1016/j.jbc.2021.100731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166775/
https://www.ncbi.nlm.nih.gov/pubmed/33933449
http://dx.doi.org/10.1016/j.jbc.2021.100731

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