Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics

To expand the antisense oligonucleotide (ASO) fluorescence labeling toolbox beyond covalent conjugation of external dyes (e.g. ATTO-, Alexa Fluor-, or cyanine dyes), we herein explore fluorescent base analogues (FBAs) as a novel approach to endow fluorescent properties to ASOs. Both cytosine and ade...

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Detalles Bibliográficos
Autores principales: Nilsson, Jesper R., Baladi, Tom, Gallud, Audrey, Baždarević, Dženita, Lemurell, Malin, Esbjörner, Elin K., Wilhelmsson, L. Marcus, Dahlén, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166847/
https://www.ncbi.nlm.nih.gov/pubmed/34059711
http://dx.doi.org/10.1038/s41598-021-90629-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166847/
https://www.ncbi.nlm.nih.gov/pubmed/34059711
http://dx.doi.org/10.1038/s41598-021-90629-1

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