In vivo targeting of lentiviral vectors pseudotyped with the Tupaia paramyxovirus H glycoprotein bearing a cell-specific ligand

Despite their exceptional capacity for transgene delivery ex vivo, lentiviral (LV) vectors have been slow to demonstrate clinical utility in the context of in vivo applications. Unresolved safety concerns related to broad LV vector tropism have limited LV vectors to ex vivo applications. Here, we re...

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Detalles Bibliográficos
Autores principales: Argaw, Takele, Marino, Michael P., Timmons, Andrew, Eldridge, Lindsey, Takeda, Kazuyo, Li, Pingjuan, Kwilas, Anna, Ou, Wu, Reiser, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166926/
https://www.ncbi.nlm.nih.gov/pubmed/34141822
http://dx.doi.org/10.1016/j.omtm.2021.04.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166926/
https://www.ncbi.nlm.nih.gov/pubmed/34141822
http://dx.doi.org/10.1016/j.omtm.2021.04.012

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