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Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons
ALS is characterized by progressive inability to execute movements. Motor neurons innervating fast-twitch muscle-fibers preferentially degenerate. The reason for this differential vulnerability and its consequences on motor output is not known. Here, we uncover that fast motor neurons receive strong...
Autores principales: | Allodi, Ilary, Montañana-Rosell, Roser, Selvan, Raghavendra, Löw, Peter, Kiehn, Ole |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166981/ https://www.ncbi.nlm.nih.gov/pubmed/34059686 http://dx.doi.org/10.1038/s41467-021-23224-7 |
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