Cargando…

Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesity

Histone lysine demethylase 6a (Kdm6a) mediates the removal of repressive trimethylation from histone H3 lysine 27 (H3K27me3) to activate target gene expression. Obesity is associated with metabolic inflammation, and adipose tissue macrophages (ATMs) are key players orchestrating metabolic inflammati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jun, Xu, Xing, Li, Yan, Li, Fan, Zhang, Jianjun, Xu, Qin, Chen, Wantao, Wei, Yan, Wang, Xu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167088/ https://www.ncbi.nlm.nih.gov/pubmed/33303977 http://dx.doi.org/10.1038/s41418-020-00694-8

Ejemplares similares

Cancer-associated Fibroblast-derived IL-6 Promotes Head and Neck Cancer Progression via the Osteopontin-NF-kappa B Signaling Pathway
por: Qin, Xing, et al.
Publicado: (2018)

Cancer-associated Fibroblast-derived IL-6 Promotes Head and Neck Cancer Progression via the Osteopontin-NF-kappa B Signaling Pathway: Erratum
por: Qin, Xing, et al.
Publicado: (2022)

Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet
por: Xu, Liang, et al.
Publicado: (2022)

Dihydroartemisinin suppresses bladder cancer cell invasion and migration by regulating KDM3A and p21
por: Wang, Tao, et al.
Publicado: (2020)

Prenatal inflammation causes obesity and abnormal lipid metabolism via impaired energy expenditure in male offspring
por: Ni, Meng, et al.
Publicado: (2022)

Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma
por: Xu, Xing, et al.
Publicado: (2021)

A new gamboge derivative Compound 2 inhibits cancer stem-like cells via suppressing EGFR tyrosine phosphorylation in head and neck squamous cell carcinoma
por: Deng, Rongxin, et al.
Publicado: (2013)

Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression
por: Wang, Xiaoning, et al.
Publicado: (2019)

Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure
por: Ying, Lingwen, et al.
Publicado: (2021)

KDM3A and KDM3B Maintain Naïve Pluripotency Through the Regulation of Alternative Splicing
por: Dillingham, Caleb, et al.
Publicado: (2023)

Phytohemagglutinin ameliorates HFD-induced obesity by increasing energy expenditure
por: Zhang, Yunxia, et al.
Publicado: (2021)

Targeting Energy Expenditure—Drugs for Obesity Treatment
por: Jimenez-Munoz, Carlos M., et al.
Publicado: (2021)

Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
por: Li, Ping, et al.
Publicado: (2012)

Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice
por: Lin, Shaojian, et al.
Publicado: (2022)

TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis
por: Qin, Xing, et al.
Publicado: (2016)

Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4
por: Huang, Zhiqiang, et al.
Publicado: (2023)

Cancer stem-like cell related protein CD166 degrades through E3 ubiquitin ligase CHIP in head and neck cancer
por: Xiao, Meng, et al.
Publicado: (2017)

CD73 in small extracellular vesicles derived from HNSCC defines tumour‐associated immunosuppression mediated by macrophages in the microenvironment
por: Lu, Tingwei, et al.
Publicado: (2022)

Swertiamarin ameliorates diet-induced obesity by promoting adipose tissue browning and oxidative metabolism in preexisting obese mice: Swertiamarin reverses obesity by enhancing energy expenditure
por: Zhu, Yuqin, et al.
Publicado: (2022)

Awakening KDM5B to defeat leukemia
por: Chan, Lok Hei, et al.
Publicado: (2022)

The one-two punch: Retinoic acid suppresses obesity both by promoting energy expenditure and by inhibiting adipogenesis
por: Noy, Noa
Publicado: (2013)

Cancer-associated fibroblasts promote cancer cell growth through a miR-7-RASSF2-PAR-4 axis in the tumor microenvironment
por: Shen, Zongze, et al.
Publicado: (2016)

KDM5 histone demethylases repress immune response via suppression of STING
por: Wu, Lizhen, et al.
Publicado: (2018)

KDM6 Demethylases and Their Roles in Human Cancers
por: Hua, Chunyan, et al.
Publicado: (2021)

Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling
por: Lađinović, Dijana, et al.
Publicado: (2020)

Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity‐Related Properties
por: Wei, Yan, et al.
Publicado: (2021)

UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration
por: Guo, Zhu, et al.
Publicado: (2020)

Knockout of the Histone Demethylase Kdm3b Decreases Spermatogenesis and Impairs Male Sexual Behaviors
por: Liu, Zhaoliang, et al.
Publicado: (2015)

LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus
por: Jiang, Yingying, et al.
Publicado: (2019)

Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF‐1α
por: Wang, Xiaoning, et al.
Publicado: (2023)

Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5
por: Qin, Xing, et al.
Publicado: (2019)

Energy Expenditure Estimation of Tabata by Combining Acceleration and Heart Rate
por: Yan, Yiping, et al.
Publicado: (2022)

Energy Expenditure in Pregnant Women with Obesity Does Not Support Energy Intake Recommendations
por: Most, Jasper, et al.
Publicado: (2018)

Lower energy expenditures in infants from obese biological mothers
por: Rising, Russell, et al.
Publicado: (2008)

Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
por: Seo, Jin, et al.
Publicado: (2009)

Energy Expenditure in Obese Children with Pseudohypoparathyroidism Type 1a
por: Shoemaker, Ashley H., et al.
Publicado: (2012)

Telemedical assessment of the level of energy expenditure in overweight and obese individuals
por: Saran, Tomasz, et al.
Publicado: (2017)

Chrysin mitigated obesity by regulating energy intake and expenditure in rats()
por: Pai, Sarayu A., et al.
Publicado: (2019)

RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A
por: Chen, Dong-Bo, et al.
Publicado: (2020)

M1-like tumor-associated macrophages activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma
por: Xiao, Meng, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_omp4qqeo7jjnvtfjv89lj4kunu