CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism

The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL isoforms (ORMDL1-3) are negative regulators of SPT. However, the roles of individual ORMDL isoforms are unclear. Using siRNA a...

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Detalles Bibliográficos
Autores principales: Green, Christopher D., Weigel, Cynthia, Oyeniran, Clement, James, Briana N., Davis, Deanna, Mahawar, Usha, Newton, Jason, Wattenberg, Binks W., Maceyka, Michael, Spiegel, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167824/
https://www.ncbi.nlm.nih.gov/pubmed/33939982
http://dx.doi.org/10.1016/j.jlr.2021.100082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167824/
https://www.ncbi.nlm.nih.gov/pubmed/33939982
http://dx.doi.org/10.1016/j.jlr.2021.100082

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