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Transfer of stabilising mutations between different secondary active transporter families

Integral membrane transporters play essential roles in the movement of substrates across biological membranes. One approach to produce transporters suitable for structural studies is to introduce mutations that reduce conformational flexibility and increase stability. However, it can be difficult to...

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Detalles Bibliográficos
Autores principales: Cecchetti, Cristina, Scull, Nicola J., Mohan, Thotegowdanapalya C., Alguel, Yilmaz, Jones, Alexandra M. C., Cameron, Alexander D., Byrne, Bernadette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167854/
https://www.ncbi.nlm.nih.gov/pubmed/33932145
http://dx.doi.org/10.1002/2211-5463.13168