Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK signaling

BACKGROUND: Exosomes have emerged as critical mediators of intercellular communication. Hypoxia is widely recognized as a key regulator of tumor aggressiveness, and significantly affects exosome release by tumor cells. However, the effects of exosomes derived from hypoxic lung adenocarcinoma (LUAD)...

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Detalles Bibliográficos
Autores principales: Yu, Fengqiang, Liang, Mingqiang, Huang, Yu, Wu, Weidong, Zheng, Bin, Chen, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167983/
https://www.ncbi.nlm.nih.gov/pubmed/34074322
http://dx.doi.org/10.1186/s13046-021-01979-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167983/
https://www.ncbi.nlm.nih.gov/pubmed/34074322
http://dx.doi.org/10.1186/s13046-021-01979-7

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