HGG-38. DE NOVO PYRIMIDINE SYNTHESIS INHIBITION INDUCES REPLICATION CATASTROPHE MEDIATED CELL DEATH IN DIFFUSE MIDLINE GLIOMA

Diffuse midline gliomas (DMG) are aggressive and lethal pediatric brain tumors that cannot be cured by conventional therapeutic modalities. Using a genome wide CRISPR screen we identified the de novo pyrimidine biosynthesis pathway as a metaboilic vulnerability in DMGs. BAY2402234 is a small molecul...

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Detalles Bibliográficos
Autores principales: Pal, Sharmistha, Kaplan, Jakub, Stopka, Sylwia, Regan, Michael, Kann, Benjamin, Agar, Nathalie, Stiles, Charles, Cooney, Tabitha, Mueller, Sabine, Chowdhury, Dipanjan, Haas-Kogan, Daphne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
High Grade Gliomas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168089/
http://dx.doi.org/10.1093/neuonc/noab090.102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168089/
http://dx.doi.org/10.1093/neuonc/noab090.102

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