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HGG-13. BRAIN DISTRIBUTION AND CLEARANCE OF ALISERTIB IS LIMITED BY PGP AND BCRP EFFLUX PUMPS AND DEPENDENT UPON DELIVERY METHOD
Diffuse midline gliomas (DMGs) harboring the H3K27M mutation are highly aggressive, uniformly fatal brain tumors that primarily occur in children. The blood-brain barrier (BBB), including drug efflux pumps, prevent numerous drugs from reaching CNS tumors at cytotoxic concentrations. Alisertib is an...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168113/ http://dx.doi.org/10.1093/neuonc/noab090.079 |