HGG-12. HUMAN IPSC-DERIVED H3.3K27M NEUROSPHERES: A NOVEL MODEL FOR INVESTIGATING DIPG PATHOGENESIS AND DRUG RESPONSE

Diffuse intrinsic pontine glioma (DIPG) is a subset of high-grade glioma that occurs predominantly in children and has no cure. Up to 80% of DIPG harbor a heterozygous point mutation that results in a lysine 27 to methionine substitution in histone variant H3.3 (H3.3K27M). Existing DIPG models have...

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Detalles Bibliográficos
Autores principales: Skinner, Kasey, Koga, Tomoyuki, Miki, Shunichiro, Gruener, Robert F, Huang, R Stephanie, Furnari, Frank, Miller, C Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
High Grade Gliomas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168137/
http://dx.doi.org/10.1093/neuonc/noab090.078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168137/
http://dx.doi.org/10.1093/neuonc/noab090.078

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