RARE-02. POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse intrinsic pontine glioma (DIPG) is an aggressive paediatric brainstem tumour, with a median survival of less than 1 year. Polyamines are intracellular polycations that control important aspects of cell growth and are often upregulated in cancer. Difluoromethylornithine (DFMO) is an FDA-appro...

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Detalles Bibliográficos
Autores principales: Khan, Aaminah, Gamble, Laura, Upton, Dannielle, Yu, Denise, Pandher, Ruby, Mayoh, Chelsea, Burns, Mark R, Norris, Murray D, Haber, Michelle, Tsoli, Maria, Ziegler, David S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Rare Tumors/Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168151/
http://dx.doi.org/10.1093/neuonc/noab090.163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168151/
http://dx.doi.org/10.1093/neuonc/noab090.163

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