BIOL-05. MAPK PATHWAY INHIBITION SENSITIZES TO IMMUNOTHERAPY IN BRAF-MUTANT GLIOMAS

BACKGROUND: BRAF alterations frequently occur in pediatric low-grade gliomas. Previously, we showed that dabrafenib and trametinib (D+T) that target MAPK pathway can mediate the antitumor effect in a preclinical model of BRAF-mutant glioma (PMC5342782). Here, we further investigate the effect of MAP...

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Detalles Bibliográficos
Autores principales: Park, Jong-Whi, Barrette, Anne-Marie, Wang, Wei, Grossauer, Stefan, Grant, Gerald, Lau, Ken, Pitteri, Sharon, Monje, Michelle, Petritsch, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168157/
http://dx.doi.org/10.1093/neuonc/noab090.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168157/
http://dx.doi.org/10.1093/neuonc/noab090.012

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