Cargando…
BIOL-05. MAPK PATHWAY INHIBITION SENSITIZES TO IMMUNOTHERAPY IN BRAF-MUTANT GLIOMAS
BACKGROUND: BRAF alterations frequently occur in pediatric low-grade gliomas. Previously, we showed that dabrafenib and trametinib (D+T) that target MAPK pathway can mediate the antitumor effect in a preclinical model of BRAF-mutant glioma (PMC5342782). Here, we further investigate the effect of MAP...
Autores principales: | Park, Jong-Whi, Barrette, Anne-Marie, Wang, Wei, Grossauer, Stefan, Grant, Gerald, Lau, Ken, Pitteri, Sharon, Monje, Michelle, Petritsch, Claudia |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168157/ http://dx.doi.org/10.1093/neuonc/noab090.012 |
Ejemplares similares
-
LGG-05. GENERATION OF NOVEL MOUSE MODELS FOR BRAF V600E MUTANT GLIOMAGENESIS TO GAIN MECHANISTIC INSIGHTS INTO TUMOR FORMATION AND PROGRESSION
por: K. Petritsch, Claudia, et al.
Publicado: (2021) -
BIOL-09. HNRNPA1 SPLICED VARIANT: KEY RESISTANT GENE SIGNATURE IN GLIOMAS
por: Yadav, Ajay
Publicado: (2021) -
BIOL-05. IDENTIFICATION AND VALIDATION OF PA2G4 AS A POTENTIAL THERAPEUTIC TARGET IN PEDIATRIC DIFFUSE GLIOMAS
por: Sirhan, Zaid, et al.
Publicado: (2023) -
BIOL-06. UNDERSTANDING OLIGODENDROCYTE PROGENITOR CELL CONTRIBUTION TO GLIOMAGENESIS USING A NOVEL PHARMACOGENETIC ABLATION TOOL
por: Xing, Lulu, et al.
Publicado: (2023) -
Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAF(V600E) targeted inhibition in a novel syngeneic murine glioma model
por: Grossauer, Stefan, et al.
Publicado: (2016)