EMBR-07. MYC BUT NOT MYCN GENERATES AGGRESSIVE GROUP 3 MEDULLOBLASTOMA BY ARF PATHWAY SUPPRESSION

Medulloblastoma (MB), the most common malignant pediatric brain tumor, often harbor MYC amplifications and arise in the presence of a functional p53 suppressor protein. To elucidate the mechanism behind this inexplicable tumor development we generated an inducible, immunocompetent transgenic mouse m...

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Detalles Bibliográficos
Autores principales: Mainwaring, Oliver, Weishaupt, Holger, Hutter, Sonja, Zhao, Miao, Rosén, Gabriela, Breinschmid, Laura, Verbaan, Annemieke, Sundström, Anders, Annusver, Karl, Kasper, Maria, Swartling, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Embryonal Tumors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168170/
http://dx.doi.org/10.1093/neuonc/noab090.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168170/
http://dx.doi.org/10.1093/neuonc/noab090.025

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