HGG-39. ALTERNATIVE SPLICING OF NEUROFIBROMIN 1 IS ASSOCIATED WITH ELEVATED MAPK ACTIVITY AND POOR PROGNOSIS IN HIGH-GRADE GLIOMA

Despite a good understanding of the coding mutations underlying high-grade gliomas (HGG), their prognosis remains poor. We sought to characterize their transcriptional alterations and how this contributes to pathogenesis. We analyzed a large cohort of pediatric HGG (pHGG) by DNA sequencing (n=79) an...

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Detalles Bibliográficos
Autores principales: Siddaway, Robert, Milos, Scott, Vadivel, Arun, Dobson, Tara, Swaminathan, Jyothishmathi, Ryall, Scott, Pajovic, Sanja, Nazarian, Javad, Becher, Oren, Brudno, Michael, Ramani, Arun, Gopalakrishnan, Vidya, Hawkins, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
High Grade Gliomas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168180/
http://dx.doi.org/10.1093/neuonc/noab090.103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168180/
http://dx.doi.org/10.1093/neuonc/noab090.103

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