ATRT-09. IDENTIFICATION OF POTENTIAL GENETIC DRIVERS OF METHOTREXATE (MTX) RESISTANCE IN ATYPICAL TERATOID RHABDOID TUMOURS (ATRT) THROUGH A GENOME-WIDE RNAI SCREEN

ATRT of the CNS constitute a group of rare and aggressive early childhood tumors with poor prognosis. While there are differing chemotherapeutic regimens for ATRT, high-dose MTX is a crucial component of many therapeutic protocols. Currently, the biological mechanisms contributing to the generation...

Descripción completa

Detalles Bibliográficos
Autores principales: Kannappan, Sunand, Gupa, Mehul, Kang, SungMyung, Tran, Andy Son, Thakur, Satbir Singh, Jain, Mohit, Narendran, Aru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Atypical Teratoid Rhabdoid Tumors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168191/
http://dx.doi.org/10.1093/neuonc/noab090.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168191/
http://dx.doi.org/10.1093/neuonc/noab090.008

Ejemplares similares