EMBR-23. KIF11 DEPENDENCY ON P53 MUTATIONAL STATUS IN MEDULLOBLASTOMA

INTRODUCTION: KIF11, a mitotic kinesin, is a component responsible for assembly and maintenance of mitotic spindle during mitosis. Tumor cells can upregulate KIF11. Inhibition of KIF11 results monopolar spindle formation, resulting in monoastral mitosis in cells. This activates the spindle assembly...

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Detalles Bibliográficos
Autores principales: Huang, Shiying, Karthik, Sekar, Lin, Qi, Du, YuChen, Lau, Ching C, Adekunle, Adesina, Su, Jack M F, Major, Angela, Elghetany, M Tarek, Hui, Kam-Man, Li, Xiaonan, Teo, Wan-Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Embryonal Tumors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168209/
http://dx.doi.org/10.1093/neuonc/noab090.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168209/
http://dx.doi.org/10.1093/neuonc/noab090.041

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