EPCT-01. A NOVEL PEPTIDE VACCINE DIRECTED TO CMV PP65 FOR TREATMENT OF RECURRENT MALIGNANT GLIOMA AND MEDULLOBLASTOMA IN CHILDREN AND YOUNG ADULTS: PRELIMINARY RESULTS OF A PHASE I TRIAL

INTRODUCTION: The cytomegalovirus (CMV) antigen, pp65, is ubiquitously expressed in malignant glioma and medulloblastoma but not in healthy brain. The objective of this Phase I trial (NCT03299309) was to assess the safety and feasibility of a novel pp65 peptide vaccine (PEP-CMV) in children and youn...

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Detalles Bibliográficos
Autores principales: Thompson, Eric, Landi, Daniel, Archer, Gerald, Lipp, Eric, Walter, Ashley, Archambault, Bridget, Balajonda, Bea, Flahiff, Charlene, Jaggers, Denise, Herndon, James, Buckley, Evan, Schroeder, Kristin, Randazzo, Dina, Desjardins, Annick, Johnson, Margaret, Peters, Katherine, Khasraw, Mustafa, Malinzak, Michael, Michell, Duane, Ashley, David, Sampson, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Translational/Early Phase Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168240/
http://dx.doi.org/10.1093/neuonc/noab090.187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168240/
http://dx.doi.org/10.1093/neuonc/noab090.187

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