EPEN-07. SINGLE-CELL RNA SEQUENCING IDENTIFIES A UNIQUE MYELOID SUBPOPULATION ASSOCIATED WITH MESENCHYMAL TUMOR SUBPOPULATION IN POOR OUTCOME PEDIATRIC EPENDYMOMA

We have previously shown immune gene phenotype variations between posterior fossa ependymoma subgroups. PFA1 tumors chronically secrete IL-6, which induces secretion of myeloid cell IL-8 and pushes the infiltrating myeloid cells to an immune suppressive function. In contrast, PFA2 tumors have a more...

Descripción completa

Detalles Bibliográficos
Autores principales: Griesinger, Andrea, Riemondy, Kent, Donson, Andrew, Willard, Nicholas, Prince, Eric, Harris, Faith, Amani, Vladimir, Grimaldo, Enrique, Hankinson, Todd, Grundy, Richard, Jackson, Andrew, Foreman, Nicholas, Ritzmann, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Ependymoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168243/
http://dx.doi.org/10.1093/neuonc/noab090.057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168243/
http://dx.doi.org/10.1093/neuonc/noab090.057

Ejemplares similares