TMOD-06. LOSS OF DICER COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE METASTATIC MEDULLOBLASTOMA

To determine the role of microRNA regulation in brain tumor development, we incorporated a conditional allele of the microRNA processing enzyme Dicer to a previously characterized glioma mouse model based on inactivation of the tumor suppressors Nf1, Trp53, and Pten using the Nestin-creER(T2) transg...

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Detalles Bibliográficos
Autores principales: Alcantara Llaguno, Sheila, Nazarenko, Inga, Chen, Yuntao, Sun, Daochun, Rocca, Gaspare La, Pedraza, Alicia, Gudenas, Brian, Saulnier, Olivier, Burns, Dennis, Bale, Tejus, Northcott, Paul, Taylor, Michael, Ventura, Andrea, Parada, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168245/
http://dx.doi.org/10.1093/neuonc/noab090.147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168245/
http://dx.doi.org/10.1093/neuonc/noab090.147

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