ERK/Drp1‐dependent mitochondrial fission contributes to HMGB1‐induced autophagy in pulmonary arterial hypertension

OBJECTIVES: High‐mobility group box‐1 (HMGB1) and aberrant mitochondrial fission mediated by excessive activation of GTPase dynamin‐related protein 1 (Drp1) have been found to be elevated in patients with pulmonary arterial hypertension (PAH) and critically implicated in PAH pathogenesis. However, i...

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Detalles Bibliográficos
Autores principales: Feng, Wei, Wang, Jian, Yan, Xin, Zhang, Qianqian, Chai, Limin, Wang, Qingting, Shi, Wenhua, Chen, Yuqian, Liu, Jin, Qu, Zhan, Li, Shaojun, Xie, Xinming, Li, Manxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168414/
https://www.ncbi.nlm.nih.gov/pubmed/33948998
http://dx.doi.org/10.1111/cpr.13048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168414/
https://www.ncbi.nlm.nih.gov/pubmed/33948998
http://dx.doi.org/10.1111/cpr.13048

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