Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants

Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of LPS has been related with reduced endotoxicity in...

Descripción completa

Detalles Bibliográficos
Autores principales: Pérez-Ortega, Jesús, Van Harten, Roel M., Van Boxtel, Ria, Plisnier, Michel, Louckx, Marc, Ingels, Dominique, Haagsman, Henk P., Tommassen, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168481/
https://www.ncbi.nlm.nih.gov/pubmed/34053396
http://dx.doi.org/10.1080/21505594.2021.1929037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168481/
https://www.ncbi.nlm.nih.gov/pubmed/34053396
http://dx.doi.org/10.1080/21505594.2021.1929037

Ejemplares similares