RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks

Hematological malignancies are characterized by a block in differentiation, which in many cases is caused by recurrent mutations affecting the activity of hematopoietic transcription factors. RUNX1-EVI1 is a fusion protein encoded by the t(3;21) translocation linking two transcription factors requir...

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Detalles Bibliográficos
Autores principales: Kellaway, Sophie G., Keane, Peter, Kennett, Ella, Bonifer, Constanze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168488/
https://www.ncbi.nlm.nih.gov/pubmed/32299907
http://dx.doi.org/10.3324/haematol.2019.241885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168488/
https://www.ncbi.nlm.nih.gov/pubmed/32299907
http://dx.doi.org/10.3324/haematol.2019.241885

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