Whole exome sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target

Patients diagnosed with anaplastic large cell lymphoma (ALCL) are still treated with toxic multi-agent chemotherapy and as many as 25-50% of patients relapse. To understand disease pathology and to uncover novel targets for therapy, we performed whole-exome sequencing of anaplastic lymphoma kinase (...

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Detalles Bibliográficos
Autores principales: Larose, Hugo, Prokoph, Nina, Matthews, Jamie D., Schlederer, Michaela, Högler, Sandra, Alsulami, Ali F., Ducray, Stephen P., Nuglozeh, Edem, Fazaludeen, Mohammad Feroze, Elmouna, Ahmed, Ceccon, Monica, Mologni, Luca, Gambacorti-Passerini, Carlo, Hoefler, Gerald, Lobello, Cosimo, Pospisilova, Sarka, Janikova, Andrea, Woessmann, Wilhelm, Welk, Christine Damm-, Zimmermann, Mar tin, Fedorova, Alina, Malone, Andrea, Smith, Owen, Wasik, Mariusz, Inghirami, Giorgio, Lamant, Laurence, Blundell, Tom L., Klapper, Wolfram, Merkel, Olaf, Burke, G. A. Amos, Mian, Shahid, Ashankyty, Ibraheem, Kenner, Lukas, Turner, Suzanne D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168516/
https://www.ncbi.nlm.nih.gov/pubmed/32327503
http://dx.doi.org/10.3324/haematol.2019.238766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168516/
https://www.ncbi.nlm.nih.gov/pubmed/32327503
http://dx.doi.org/10.3324/haematol.2019.238766

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