PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O(6)-methylguanine DNA damage in glioblastoma

BACKGROUND: Temozolomide (TMZ) resistance in glioblastoma multiforme (GBM) is mediated by the DNA repair protein O(6)-methylguanine DNA methyltransferase (MGMT). MGMT promoter methylation (occurs in about 40% of patients) is associated with loss of MGMT expression (MGMT−) that compromises DNA repair...

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Detalles Bibliográficos
Autores principales: Wu, Shaofang, Li, Xiaolong, Gao, Feng, de Groot, John F, Koul, Dimpy, Yung, W K Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168825/
https://www.ncbi.nlm.nih.gov/pubmed/33433610
http://dx.doi.org/10.1093/neuonc/noab003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168825/
https://www.ncbi.nlm.nih.gov/pubmed/33433610
http://dx.doi.org/10.1093/neuonc/noab003

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