Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice

BACKGROUND: One of the major hallmarks of Alzheimer's disease (AD)is the aberrant modification and aggregation of the microtubule‐associated protein Tau . The extent of Tau pathology correlates with cognitive decline, strongly implicating Tau in the pathogenesis of the disease. Because the inhi...

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Detalles Bibliográficos
Autores principales: Anglada‐Huguet, Marta, Rodrigues, Sara, Hochgräfe, Katja, Mandelkow, Eckhard, Mandelkow, Eva‐Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168941/
https://www.ncbi.nlm.nih.gov/pubmed/34095439
http://dx.doi.org/10.1002/trc2.12170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168941/
https://www.ncbi.nlm.nih.gov/pubmed/34095439
http://dx.doi.org/10.1002/trc2.12170

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