Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

Members of the SH3- and ankyrin repeat (SHANK) protein family are considered as master scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations within the canonical SHANK3 isoform have been proposed as causative for the development of autism spectrum disorders (ASD...

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Detalles Bibliográficos
Autores principales: Bucher, Michael, Niebling, Stephan, Han, Yuhao, Molodenskiy, Dmitry, Hassani Nia, Fatemeh, Kreienkamp, Hans-Jürgen, Svergun, Dmitri, Kim, Eunjoon, Kostyukova, Alla S, Kreutz, Michael R, Mikhaylova, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169116/
https://www.ncbi.nlm.nih.gov/pubmed/33945465
http://dx.doi.org/10.7554/eLife.66165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169116/
https://www.ncbi.nlm.nih.gov/pubmed/33945465
http://dx.doi.org/10.7554/eLife.66165

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