p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) that exist on a spectrum of neurodegenerative disease. A hallmark of pathology is cytoplasmic TDP-43 aggregates within neurons, observed in 97% of ALS cases and ~ 50% of FTLD cases. This mislocalisation from the nucleus...

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Detalles Bibliográficos
Autores principales: Foster, A. D., Flynn, L. L., Cluning, C., Cheng, F., Davidson, J. M., Lee, A., Polain, N., Mejzini, R., Farrawell, N., Yerbury, J. J., Layfield, R., Akkari, P. A., Rea, S. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169680/
https://www.ncbi.nlm.nih.gov/pubmed/34075102
http://dx.doi.org/10.1038/s41598-021-90822-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169680/
https://www.ncbi.nlm.nih.gov/pubmed/34075102
http://dx.doi.org/10.1038/s41598-021-90822-2

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