Cargando…

Short lifespan of syngeneic transplanted MSC is a consequence of in vivo apoptosis and immune cell recruitment in mice

Mesenchymal stromal cells (MSC) are attractive tools for cell-based therapy, yet the mechanisms underlying their migration and survival post-transplantation are unclear. Accumulating evidence indicates that MSC apoptosis modulates both innate and adaptive immune responses which impact on MSC therape...

Descripción completa

Detalles Bibliográficos
Autores principales:	Preda, Mihai Bogdan, Neculachi, Carmen Alexandra, Fenyo, Ioana Madalina, Vacaru, Ana-Maria, Publik, Mihai Alin, Simionescu, Maya, Burlacu, Alexandrina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169682/ https://www.ncbi.nlm.nih.gov/pubmed/34075029 http://dx.doi.org/10.1038/s41419-021-03839-w

Ejemplares similares

Evidence of mesenchymal stromal cell adaptation to local microenvironment following subcutaneous transplantation
por: Preda, Mihai Bogdan, et al.
Publicado: (2020)

Enhanced Suppression of Immune Cells In Vitro by MSC Overexpressing FasL
por: Vacaru, Ana-Maria, et al.
Publicado: (2020)

Dual Stem Cell Therapy Improves the Myocardial Recovery Post-Infarction through Reciprocal Modulation of Cell Functions
por: Popescu, Sinziana, et al.
Publicado: (2021)

Identification of a Hematopoietic Cell Population Emerging From Mouse Bone Marrow With Proliferative Potential In Vitro and Immunomodulatory Capacity
por: Marinescu, Catalina-Iolanda, et al.
Publicado: (2021)

MiR-29a Increase in Aging May Function as a Compensatory Mechanism Against Cardiac Fibrosis Through SERPINH1 Downregulation
por: Rusu-Nastase, Evelyn Gabriela, et al.
Publicado: (2022)

A procedure for in vitro evaluation of the immunosuppressive effect of mouse mesenchymal stem cells on activated T cell proliferation
por: Marinescu, Catalina-Iolanda, et al.
Publicado: (2021)

Evaluation of the Ability of Nanostructured PEI-Coated Iron Oxide Nanoparticles to Incorporate Cisplatin during Synthesis
por: Tutuianu, Raluca, et al.
Publicado: (2017)

miRNAs generated from Meg3-Mirg locus are downregulated during aging
por: Lupan, Ana-Mihaela, et al.
Publicado: (2021)

Treatment with Mesenchymal Stromal Cells Overexpressing Fas-Ligand Ameliorates Acute Graft-versus-Host Disease in Mice
por: Vacaru, Andrei Mircea, et al.
Publicado: (2022)

Inflammatory status of the pancreas in NOD mice that do not develop overt diabetes
por: Catrina, Ana-Maria, et al.
Publicado: (2021)

Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes
por: Manea, Simona-Adriana, et al.
Publicado: (2018)

K2 Transfection System Boosts the Adenoviral Transduction of Murine Mesenchymal Stromal Cells
por: Dumitrescu, Madalina, et al.
Publicado: (2021)

Heart function assessment during aging in apolipoprotein E knock-out mice
por: Liehn, Elisa A., et al.
Publicado: (2021)

Differential action of glucocorticoids on apolipoprotein E gene expression in macrophages and hepatocytes
por: Trusca, Violeta Georgeta, et al.
Publicado: (2017)

The Mechanism of Bisphenol A Atherogenicity Involves Apolipoprotein A-I Downregulation through NF-κB Activation
por: Trusca, Violeta G., et al.
Publicado: (2019)

Collagen regulates the ability of endothelial progenitor cells to protect hypoxic myocardium through a mechanism involving miR‐377/VE‐PTP axis
por: Rosca, Ana‐Maria, et al.
Publicado: (2018)

Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis
por: Manea, Simona-Adriana, et al.
Publicado: (2019)

Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe
por: Manea, Simona-Adriana, et al.
Publicado: (2021)

A Systematic Approach of the Intrauterine Morphogenesis of the Human Palpebral Apparatus
por: Munteanu, Octavian, et al.
Publicado: (2022)

VLA4-Enhanced Allogeneic Endothelial Progenitor Cell-Based Therapy Preserves the Aortic Valve Function in a Mouse Model of Dyslipidemia and Diabetes
por: Filippi, Alexandru, et al.
Publicado: (2022)

The Effect of Calcium-Silicate Cements on Reparative Dentinogenesis Following Direct Pulp Capping on Animal Models
por: Andrei, Mihai, et al.
Publicado: (2021)

Particularities of Telework Applicable to the Health System in the Context of the COVID-19 Pandemic
por: Filip, Alina, et al.
Publicado: (2022)

Antecedents and Consequences of Banking Customers’ Behavior towards Social Media: Evidence from an Emerging Economy
por: Zhang, Lei, et al.
Publicado: (2022)

Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice
por: Kovina, Marina V., et al.
Publicado: (2019)

CCR4 Blockade Diminishes Intratumoral Macrophage Recruitment and Augments Survival of Syngeneic Pancreatic Cancer-Bearing Mice
por: Khabipov, Aydar, et al.
Publicado: (2023)

The Quest for Neurodegenerative Disease Treatment—Focusing on Alzheimer’s Disease Personalised Diets
por: Palimariciuc, Matei, et al.
Publicado: (2023)

Integrins α4β1 and αVβ3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease
por: Filippi, Alexandru, et al.
Publicado: (2020)

Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier
por: Teleanu, Raluca Ioana, et al.
Publicado: (2022)

Nanocoatings for Chronic Wound Repair—Modulation of Microbial Colonization and Biofilm Formation
por: Mihai, Mara Mădălina, et al.
Publicado: (2018)

DPP4 Inhibitor Sitagliptin Enhances Lymphocyte Recruitment and Prolongs Survival in a Syngeneic Ovarian Cancer Mouse Model
por: Wilson, Amy L., et al.
Publicado: (2021)

The Risk of Sarcoidosis Misdiagnosis and the Harmful Effect of Corticosteroids When the Disease Picture Is Incomplete
por: Arcana, Raluca Ioana, et al.
Publicado: (2023)

Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation
por: Mihaila, Andreea C., et al.
Publicado: (2021)

A murine preclinical syngeneic transplantation model for breast cancer precision medicine
por: Federico, Lorenzo, et al.
Publicado: (2017)

Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal
por: Selman, Colin, et al.
Publicado: (2013)

Cardiovascular consequences of maternal obesity throughout the lifespan in first generation sheep
por: Pankey, Christopher L., et al.
Publicado: (2022)

Jessie Dobson, MSc.
por: LeFanu, W
Publicado: (1985)

Synchro-Cyclotron (MSC)
Publicado: (1964)

Synchro-Cyclotron (MSC)
Publicado: (1965)

Synchro-Cyclotron (MSC)
Publicado: (1964)

Synchro-Cyclotron (MSC)
Publicado: (1965)

Cannot write session to /tmp/vufind_sessions/sess_04clr43g2t0p7kcnebl2in8597