The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane

Tumor suppressor PTEN, the second most highly mutated protein in cancer, dephosphorylates signaling lipid PIP(3) produced by PI3Ks. Excess PIP(3) promotes cell proliferation. The mechanism at the membrane of this pivotal phosphatase is unknown hindering drug discovery. Exploiting explicit solvent si...

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Detalles Bibliográficos
Autores principales: Jang, Hyunbum, Smith, Iris Nira, Eng, Charis, Nussinov, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169795/
https://www.ncbi.nlm.nih.gov/pubmed/34113810
http://dx.doi.org/10.1016/j.isci.2021.102438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169795/
https://www.ncbi.nlm.nih.gov/pubmed/34113810
http://dx.doi.org/10.1016/j.isci.2021.102438

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