Cargando…

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane

Tumor suppressor PTEN, the second most highly mutated protein in cancer, dephosphorylates signaling lipid PIP(3) produced by PI3Ks. Excess PIP(3) promotes cell proliferation. The mechanism at the membrane of this pivotal phosphatase is unknown hindering drug discovery. Exploiting explicit solvent si...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jang, Hyunbum, Smith, Iris Nira, Eng, Charis, Nussinov, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169795/ https://www.ncbi.nlm.nih.gov/pubmed/34113810 http://dx.doi.org/10.1016/j.isci.2021.102438

Ejemplares similares

How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain
por: Jang, Hyunbum, et al.
Publicado: (2023)

The quaternary assembly of KRas4B with Raf-1 at the membrane
por: Jang, Hyunbum, et al.
Publicado: (2020)

Shape shifting: The multiple conformational substates of the PTEN N‐terminal PIP(2) ‐binding domain
por: Dawson, Jennifer E., et al.
Publicado: (2022)

The mechanism of PI3Kα activation at the atomic level
por: Zhang, Mingzhen, et al.
Publicado: (2019)

Germline TTN variants are enriched in PTEN-wildtype Bannayan–Riley–Ruvalcaba syndrome
por: Yehia, Lamis, et al.
Publicado: (2017)

The mechanism of Raf activation through dimerization
por: Zhang, Mingzhen, et al.
Publicado: (2021)

Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling
por: Dudas, Balint, et al.
Publicado: (2020)

Protein conformational ensembles in function: roles and mechanisms
por: Nussinov, Ruth, et al.
Publicado: (2023)

The mechanism of activation of monomeric B-Raf V600E
por: Maloney, Ryan C., et al.
Publicado: (2021)

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2
por: Zhang, Wengang, et al.
Publicado: (2023)

Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L
por: Johnston, Sean B., et al.
Publicado: (2015)

The microbiome in PTEN hamartoma tumor syndrome
por: Byrd, Victoria, et al.
Publicado: (2017)

Phosphoinositides as membrane organizers
por: Posor, York, et al.
Publicado: (2022)

Conformational study of the protegrin-1 (PG-1) dimer interaction with lipid bilayers and its effect
por: Jang, Hyunbum, et al.
Publicado: (2007)

PI3K inhibitors: review and new strategies
por: Zhang, Mingzhen, et al.
Publicado: (2020)

Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics
por: Haspel, Nurit, et al.
Publicado: (2021)

Activation mechanisms of clinically distinct B‐Raf V600E and V600K mutants
por: Zhang, Mingzhen, et al.
Publicado: (2022)

The mechanism of activation of MEK1 by B-Raf and KSR1
por: Maloney, Ryan C., et al.
Publicado: (2022)

Regulation of the tumor suppressor PTEN by SUMO
por: González-Santamaría, J, et al.
Publicado: (2012)

PTEN: Tumor Suppressor and Metabolic Regulator
por: Chen, Chien-Yu, et al.
Publicado: (2018)

The structural basis for cancer treatment decisions
por: Nussinov, Ruth, et al.
Publicado: (2014)

Protein ensembles link genotype to phenotype
por: Nussinov, Ruth, et al.
Publicado: (2019)

Does Ras Activate Raf and PI3K Allosterically?
por: Nussinov, Ruth, et al.
Publicado: (2019)

How can same-gene mutations promote both cancer and developmental disorders?
por: Nussinov, Ruth, et al.
Publicado: (2022)

Neurodevelopmental disorders, immunity, and cancer are connected
por: Nussinov, Ruth, et al.
Publicado: (2022)

A New View of Activating Mutations in Cancer
por: Nussinov, Ruth, et al.
Publicado: (2022)

Role of the Fast Kinetics of Pyroglutamate-Modified Amyloid-β Oligomers in Membrane Binding and Membrane Permeability
por: Lee, Joon, et al.
Publicado: (2014)

Structural and Dynamic Effects of PTEN C-Terminal Tail Phosphorylation
por: Smith, Iris N., et al.
Publicado: (2022)

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B
por: Lu, Shaoyong, et al.
Publicado: (2016)

Ras isoform-specific expression, chromatin accessibility, and signaling
por: Nussinov, Ruth, et al.
Publicado: (2021)

AlphaFold, Artificial Intelligence (AI), and Allostery
por: Nussinov, Ruth, et al.
Publicado: (2022)

Higher‐order interactions of Bcr‐Abl can broaden chronic myeloid leukemia (CML) drug repertoire
por: Liu, Yonglan, et al.
Publicado: (2023)

Strategy toward Kinase-Selective Drug Discovery
por: Zhang, Mingzhen, et al.
Publicado: (2023)

Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction
por: Younger, Scott, et al.
Publicado: (2020)

PTEN Tumor-Suppressor: The Dam of Stemness in Cancer
por: Luongo, Francesca, et al.
Publicado: (2019)

Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers
por: Nussinov, Ruth, et al.
Publicado: (2019)

Computational Structural Biology: Successes, Future Directions, and Challenges
por: Nussinov, Ruth, et al.
Publicado: (2019)

Precision medicine review: rare driver mutations and their biophysical classification
por: Nussinov, Ruth, et al.
Publicado: (2019)

Correction: Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers
por: Nussinov, Ruth, et al.
Publicado: (2019)

The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma
por: Stefano, Sioletic, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_naq0q65h4kflro74obnonhh548