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The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane
Tumor suppressor PTEN, the second most highly mutated protein in cancer, dephosphorylates signaling lipid PIP(3) produced by PI3Ks. Excess PIP(3) promotes cell proliferation. The mechanism at the membrane of this pivotal phosphatase is unknown hindering drug discovery. Exploiting explicit solvent si...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169795/ https://www.ncbi.nlm.nih.gov/pubmed/34113810 http://dx.doi.org/10.1016/j.isci.2021.102438 |