Cargando…

Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits

Nearly all clinical isolates of Salmonella Typhi, the cause of typhoid fever, are antibiotic resistant. All S. Typhi isolates secrete an A(2)B(5) exotoxin called typhoid toxin to benefit the pathogen during infection. Here, we demonstrate that antibiotic-resistant S. Typhi secretes typhoid toxin con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahn, Changhwan, Yang, Yi-An, Neupane, Durga P., Nguyen, Tri, Richards, Angelene F., Sim, Ji Hyun, Mantis, Nicholas J., Song, Jeongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169802/ https://www.ncbi.nlm.nih.gov/pubmed/34113815 http://dx.doi.org/10.1016/j.isci.2021.102454

Ejemplares similares

The structural basis of Salmonella A(2)B(5) toxin neutralization by antibodies targeting the glycan-receptor binding subunits
por: Nguyen, Tri, et al.
Publicado: (2021)

The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication
por: Nguyen, Tri, et al.
Publicado: (2020)

Malnutrition and maternal vaccination against typhoid toxin
por: Neupane, Durga P., et al.
Publicado: (2022)

Neutralization of Typhoid Toxin by Alpaca-Derived, Single-Domain Antibodies Targeting the PltB and CdtB Subunits
por: Dulal, Hari P., et al.
Publicado: (2022)

Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin’s binding subunit
por: Rong, Yinghui, et al.
Publicado: (2017)

Sub-Domains of Ricin’s B Subunit as Targets of Toxin Neutralizing and Non-Neutralizing Monoclonal Antibodies
por: Yermakova, Anastasiya, et al.
Publicado: (2012)

Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin’s Enzymatic Subunit Interfere with Intracellular Toxin Transport
por: Yermakova, Anastasiya, et al.
Publicado: (2016)

Differential Neutralizing Activities of a Single Domain Camelid Antibody (V(H)H) Specific for Ricin Toxin’s Binding Subunit (RTB)
por: Herrera, Cristina, et al.
Publicado: (2014)

The Role of Typhoid Toxin in Salmonella Typhi Virulence 
por: Chong, Alexander, et al.
Publicado: (2017)

Prophylactic potential of cytolethal distending toxin B (CdtB) subunit of typhoid toxin against Typhoid fever
por: Thakur, Reena, et al.
Publicado: (2019)

The Majority of Typhoid Toxin-Positive Salmonella Serovars Encode ArtB, an Alternate Binding Subunit
por: Gaballa, A., et al.
Publicado: (2021)

Shiga Toxin Binding to Glycolipids and Glycans
por: Gallegos, Karen M., et al.
Publicado: (2012)

The prospect of orally administered monoclonal secretory IgA (SIgA) antibodies to prevent enteric bacterial infections
por: Richards, Angelene, et al.
Publicado: (2021)

Author Correction: Prophylactic potential of cytolethal distending toxin B (CdtB) subunit of typhoid toxin against Typhoid fever
por: Thakur, Reena, et al.
Publicado: (2020)

A Supercluster of Neutralizing Epitopes at the Interface of Ricin’s Enzymatic (RTA) and Binding (RTB) Subunits
por: Poon, Amanda Y., et al.
Publicado: (2017)

Direct IgG epitope mapping on bacterial AB toxins by cryo-EM
por: Nguyen, Tri, et al.
Publicado: (2021)

Conferring Virulence: Structure and Function of the chimeric A(2)B(5) Typhoid Toxin
por: Song, Jeongmin, et al.
Publicado: (2013)

Characterization of the cytolethal distending toxin (typhoid toxin) in non-typhoidal Salmonella serovars
por: Rodriguez-Rivera, Lorraine D, et al.
Publicado: (2015)

Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine
por: Novak, Hayley, et al.
Publicado: (2021)

Analysis of binding properties of pathogens and toxins using multivalent glycan microarrays
por: Kim, Hyoung Sub, et al.
Publicado: (2018)

Structure of the nuclease subunit of human mitochondrial RNase P
por: Reinhard, Linda, et al.
Publicado: (2015)

Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies
por: Vance, David J., et al.
Publicado: (2020)

Toxin Neutralization Using Alternative Binding Proteins
por: Jenkins, Timothy Patrick, et al.
Publicado: (2019)

The bulky and the sweet: How neutralizing antibodies and glycan receptors compete for virus binding
por: Dietrich, Melanie H., et al.
Publicado: (2017)

Cell transfection of purified cytolethal distending toxin B subunits allows comparing their nuclease activity while plasmid degradation assay does not
por: Pons, Benoît J., et al.
Publicado: (2019)

Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins
por: Czajka, Timothy F., et al.
Publicado: (2022)

Evolution of host adaptation in the Salmonella typhoid toxin
por: Gao, Xiang, et al.
Publicado: (2017)

Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model
por: Gibani, Malick M., et al.
Publicado: (2019)

A Multi-Specific DARPin Potently Neutralizes Shiga Toxin 2 via Simultaneous Modulation of Both Toxin Subunits
por: Zeng, Yu, et al.
Publicado: (2022)

LT-IIb(T13I), a Non-Toxic Type II Heat-Labile Enterotoxin, Augments the Capacity of a Ricin Toxin Subunit Vaccine to Evoke Neutralizing Antibodies and Protective Immunity
por: Greene, Christopher J., et al.
Publicado: (2013)

Enteric Fever Diagnosis: Current Challenges and Future Directions
por: Neupane, Durga P., et al.
Publicado: (2021)

Cell-based glycan arrays for probing glycan–glycan binding protein interactions
por: Briard, Jennie Grace, et al.
Publicado: (2018)

Human FSH Glycoform α-Subunit Asparagine(52) Glycans: Major Glycan Structural Consistency, Minor Glycan Variation in Abundance
por: Butnev, Viktor Y., et al.
Publicado: (2022)

Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans
por: Huettner, Isabella, et al.
Publicado: (2022)

Immunomodulatory Activity of Recombinant Ricin Toxin Binding Subunit B (RTB)
por: Liu, Wensen, et al.
Publicado: (2013)

Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin
por: Liu, Xiaoyu, et al.
Publicado: (2022)

Glycan-dependent cell adhesion mechanism of Tc toxins
por: Roderer, Daniel, et al.
Publicado: (2020)

Structural Basis for Binding of Neutralizing Antibodies to Clostridioides difficile Binary Toxin
por: Goldsmith, Jory A., et al.
Publicado: (2023)

Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment
por: Krautter, Franziska, et al.
Publicado: (2021)

Cleavage kinetics of human mitochondrial RNase P and contribution of its non-nuclease subunits
por: Vilardo, Elisa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_69n9skm05r8rh0vsdui6bk9k2n