TLR9- and CD40-Targeting Vaccination Promotes Human B Cell Maturation and IgG Induction via pDC-Dependent Mechanisms in Humanized Mice

Mice reconstituted with a human immune system (humanized mice) provide a robust model to study human immunology, vaccinology, and human infectious diseases. However, the development and function of B cells in humanized mice is impaired. B cells from humanized mice are immature and are impaired in Ig...

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Detalles Bibliográficos
Autores principales: Cheng, Liang, Li, Guangming, Pellegry, Caroline Marnata, Yasui, Fumihiko, Li, Feng, Zurawski, Sandra M., Zurawski, Gerard, Levy, Yves, Ting, Jenny P.-Y., Su, Lishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169971/
https://www.ncbi.nlm.nih.gov/pubmed/34093572
http://dx.doi.org/10.3389/fimmu.2021.672143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169971/
https://www.ncbi.nlm.nih.gov/pubmed/34093572
http://dx.doi.org/10.3389/fimmu.2021.672143

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