Cargando…

TLR9- and CD40-Targeting Vaccination Promotes Human B Cell Maturation and IgG Induction via pDC-Dependent Mechanisms in Humanized Mice

Mice reconstituted with a human immune system (humanized mice) provide a robust model to study human immunology, vaccinology, and human infectious diseases. However, the development and function of B cells in humanized mice is impaired. B cells from humanized mice are immature and are impaired in Ig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Liang, Li, Guangming, Pellegry, Caroline Marnata, Yasui, Fumihiko, Li, Feng, Zurawski, Sandra M., Zurawski, Gerard, Levy, Yves, Ting, Jenny P.-Y., Su, Lishan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169971/ https://www.ncbi.nlm.nih.gov/pubmed/34093572 http://dx.doi.org/10.3389/fimmu.2021.672143

Ejemplares similares

Anti-CD40 Antibody Fused to CD40 Ligand Is a Superagonist Platform for Adjuvant Intrinsic DC-Targeting Vaccines
por: Ceglia, Valentina, et al.
Publicado: (2022)

TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice
por: Godot, Véronique, et al.
Publicado: (2020)

Lupus IgA1 autoantibodies synergize with IgG to enhance pDC responses to RNA-containing immune complexes
por: Waterman, Hayley R., et al.
Publicado: (2023)

HIV-1 infection depletes human CD34(+)CD38(-) hematopoietic progenitor cells via pDC-dependent mechanisms
por: Li, Guangming, et al.
Publicado: (2017)

OA011-05. TLR-mediated pDC responses to HIV-1 ligands
por: Chang, J, et al.
Publicado: (2009)

pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation
por: Duraes, Fernanda V., et al.
Publicado: (2016)

Ribavirin Contributes to Hepatitis C Virus Suppression by Augmenting pDC Activation and Type 1 IFN Production
por: Wang, Yang, et al.
Publicado: (2015)

pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG
por: Wu, Jing, et al.
Publicado: (2019)

P17-04. Targeting HIV peptides to human dendritic cells via CD40 elicits expansion of multi-epitope polyfunctional CD4+ and CD8+ T cells in HIV patients
por: Flamar, A, et al.
Publicado: (2009)

DC Subsets Regulate Humoral Immune Responses by Supporting the Differentiation of Distinct Tfh Cells
por: Bouteau, Aurélie, et al.
Publicado: (2019)

Human DC-SIGN and CD23 do not interact with human IgG
por: Temming, A. Robin, et al.
Publicado: (2019)

Primary Human mDC1, mDC2, and pDC Dendritic Cells Are Differentially Infected and Activated by Respiratory Syncytial Virus
por: Johnson, Teresa R., et al.
Publicado: (2011)

Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation
por: Joo, HyeMee, et al.
Publicado: (2012)

What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity
por: Musumeci, Andrea, et al.
Publicado: (2019)

Author Correction: Human DC-SIGN and CD23 do not interact with human IgG
por: Temming, A. Robin, et al.
Publicado: (2020)

Slc15a4, a Gene Required for pDC Sensing of TLR Ligands, Is Required to Control Persistent Viral Infection
por: Blasius, Amanda L., et al.
Publicado: (2012)

S04-04 OA. HIV-specific responses induced by anti-CD40 targeting antibodies
por: Loof, N, et al.
Publicado: (2009)

Implications of post-translational modifications of IRF7 on pDC IFN-alpha response
por: Griesbeck, M, et al.
Publicado: (2012)

A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40
por: Chen, Jingtao, et al.
Publicado: (2015)

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development
por: Mastio, Jérôme, et al.
Publicado: (2018)

Monocytes Exposed to Immune Complexes Reduce pDC Type 1 Interferon Response to Vidutolimod
por: Sabree, Shakoora A., et al.
Publicado: (2021)

O19 - Changes in the balance between myeloid (mDC) and plasmacytoid (pDC) cell numbers in peripheral blood during childhood
por: Maggina, Paraskevi, et al.
Publicado: (2014)

The appeal of the PDC program
por: Wasow, Thomas
Publicado: (2013)

Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state
por: Swiecki, Melissa, et al.
Publicado: (2016)

Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level
por: Hagen, Sven Hendrik, et al.
Publicado: (2020)

HIV-1 T cell epitopes targeted to Rhesus macaque CD40 and DCIR: A comparative study of prototype dendritic cell targeting therapeutic vaccine candidates
por: Flamar, Anne-Laure, et al.
Publicado: (2018)

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10–producing suppressive CD4(+) T cells
por: Li, Dapeng, et al.
Publicado: (2012)

Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age
por: de Jong, Britt G, et al.
Publicado: (2017)

The Dox-pDC - A murine conditionally immortalized plasmacytoid dendritic cell line with native immune profile
por: Thieme, Sebastian, et al.
Publicado: (2018)

Surprisal, the PDC, and the primary locus of processing difficulty in relative clauses
por: Levy, Roger, et al.
Publicado: (2013)

Targeting HIV Gag p24 to DICR on dendritic cells induces T cell and potent and long-lasting antibody responses in non-human primates
por: Flamar, A, et al.
Publicado: (2012)

Bcl11a Controls Flt3 Expression in Early Hematopoietic Progenitors and Is Required for pDC Development In Vivo
por: Wu, Xiaodi, et al.
Publicado: (2013)

Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus
por: Wang, Jianwei, et al.
Publicado: (2018)

IFN-α Regulates Blimp-1 Expression via miR-23a and miR-125b in Both Monocytes-Derived DC and pDC
por: Parlato, Stefania, et al.
Publicado: (2013)

The PDC framework applied to prosody and disfluency
por: Ferreira, Fernanda
Publicado: (2013)

The Role of FOXO and PPAR Transcription Factors in Diet-Mediated Inhibition of PDC Activation and Carbohydrate Oxidation During Exercise in Humans and the Role of Pharmacological Activation of PDC in Overriding These Changes
por: Constantin-Teodosiu, Dumitru, et al.
Publicado: (2012)

The Ligands for Human IgG and Their Effector Functions
por: de Taeye, Steven W., et al.
Publicado: (2019)

Global variability of the human IgG glycome
por: Štambuk, Jerko, et al.
Publicado: (2020)

CXCR3 chemokine receptor contributes to specific CD8(+) T cell activation by pDC during infection with intracellular pathogens
por: Pontes Ferreira, Camila, et al.
Publicado: (2020)

Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells
por: Yin, Wenjie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_us5r2sig6svu64235f5ht68hak