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Replication protein A plays multifaceted roles complementary to specialized helicases in processing G-quadruplex DNA

G-quadruplexes (G4s) are non-canonical DNA structures with critical roles in DNA metabolisms. To resolve those structures that can cause replication fork stalling and genomic instability, single-stranded DNA-binding proteins and helicases are required. Here, we characterized the interplay between RP...

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Detalles Bibliográficos
Autores principales: Wang, Yi-Ran, Guo, Ting-Ting, Zheng, Ya-Ting, Lai, Chang-Wei, Sun, Bo, Xi, Xu-Guang, Hou, Xi-Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169993/
https://www.ncbi.nlm.nih.gov/pubmed/34113828
http://dx.doi.org/10.1016/j.isci.2021.102493