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PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins

Poly(ADP-ribose) polymerase 1 (PARP1) is established as a key regulator of the cellular DNA damage response and apoptosis. In addition, PARP1 participates in the global regulation of DNA repair, transcription, telomere maintenance, and inflammation response by modulating various DNA-protein and prot...

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Detalles Bibliográficos
Autores principales: Savelyev, Nikita V., Shepelev, Nikita M., Lavrik, Olga I., Rubtsova, Maria P., Dontsova, Olga A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170401/
https://www.ncbi.nlm.nih.gov/pubmed/34095104
http://dx.doi.org/10.3389/fcell.2021.621134