Efficacy and safety of early target-controlled plasma volume replacement with a balanced gelatine solution versus a balanced electrolyte solution in patients with severe sepsis/septic shock: study protocol, design, and rationale of a prospective, randomized, controlled, double-blind, multicentric, international clinical trial: GENIUS—Gelatine use in ICU and sepsis

BACKGROUND: Sepsis is associated with capillary leakage and vasodilatation and leads to hypotension and tissue hypoperfusion. Early plasma volume replacement is required to achieve haemodynamic stability (HDS) and maintain adequate tissue oxygenation. The right choice of fluids to be used for plasma...

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Autores principales:	Marx, Gernot, Zacharowski, Kai, Ichai, Carole, Asehnoune, Karim, Černý, Vladimír, Dembinski, Rolf, Ferrer Roca, Ricard, Fries, Dietmar, Molnar, Zsolt, Rosenberger, Peter, Sanchez-Sanchez, Manuel, Schürholz, Tobias, Dehnhardt, Tamara, Schmier, Sonja, von Kleist, Elke, Brauer, Ute, Simon, Tim-Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170449/ https://www.ncbi.nlm.nih.gov/pubmed/34078421 http://dx.doi.org/10.1186/s13063-021-05311-8