Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

BACKGROUND: Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fully understood for this class of antibodies. The overall a...

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Detalles Bibliográficos
Autores principales: Faresjö, Rebecca, Bonvicini, Gillian, Fang, Xiaotian T., Aguilar, Ximena, Sehlin, Dag, Syvänen, Stina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170802/
https://www.ncbi.nlm.nih.gov/pubmed/34078410
http://dx.doi.org/10.1186/s12987-021-00257-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170802/
https://www.ncbi.nlm.nih.gov/pubmed/34078410
http://dx.doi.org/10.1186/s12987-021-00257-0

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