Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder characterized by progressive muscular weakness because of the loss of dystrophin. Extracellular Ca(2+) flows into the cytoplasm through membrane tears in dystrophin-deficient myofibers, which leads to muscle contracture and necrosis....

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Detalles Bibliográficos
Autores principales: Nogami, Ken'ichiro, Maruyama, Yusuke, Sakai-Takemura, Fusako, Motohashi, Norio, Elhussieny, Ahmed, Imamura, Michihiro, Miyashita, Satoshi, Ogawa, Megumu, Noguchi, Satoru, Tamura, Yuki, Kira, Jun-ichi, Aoki, Yoshitsugu, Takeda, Shin'ichi, Miyagoe-Suzuki, Yuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170845/
https://www.ncbi.nlm.nih.gov/pubmed/33822956
http://dx.doi.org/10.1093/hmg/ddab100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170845/
https://www.ncbi.nlm.nih.gov/pubmed/33822956
http://dx.doi.org/10.1093/hmg/ddab100

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