Phosphorylation and Chromatin Tethering Prevent cGAS activation During Mitosis

The cyclic GMP-AMP synthase (cGAS) detects microbial and self-DNA in the cytosol to activate immune and inflammatory programs. cGAS also associates with chromatin especially after nuclear envelope breakdown when cells enter mitosis. How cGAS is regulated during cell cycle transition is not clear. He...

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Detalles Bibliográficos
Autores principales: Li, Tuo, Huang, Tuozhi, Du, Mingjian, Chen, Xiang, Du, Fenghe, Ren, Junyao, Chen, Zhijian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171060/
https://www.ncbi.nlm.nih.gov/pubmed/33542149
http://dx.doi.org/10.1126/science.abc5386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171060/
https://www.ncbi.nlm.nih.gov/pubmed/33542149
http://dx.doi.org/10.1126/science.abc5386

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