A novel cell-penetrating peptide targeting calpain-cleavage of PSD-95 induced by excitotoxicity improves neurological outcome after stroke

Postsynaptic density protein-95 (PSD-95) is a multidomain protein critical to the assembly of signaling complexes at excitatory synapses, required for neuronal survival and function. However, calpain-processing challenges PSD-95 function after overactivation of excitatory glutamate receptors (excito...

Descripción completa

Detalles Bibliográficos
Autores principales: Ayuso-Dolado, Sara, Esteban-Ortega, Gema M., Vidaurre, Óscar G., Díaz-Guerra, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171078/
https://www.ncbi.nlm.nih.gov/pubmed/34093851
http://dx.doi.org/10.7150/thno.60701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171078/
https://www.ncbi.nlm.nih.gov/pubmed/34093851
http://dx.doi.org/10.7150/thno.60701

Ejemplares similares