Covalent and non-covalent albumin binding of Au(i) bis-NHCs via post-synthetic amide modification

Recent decades have witnessed the emergence of Au(i) bis-N-heterocyclic carbenes (NHCs) as potential anticancer agents. However, these systems exhibit little interaction with serum proteins (e.g., human serum albumin), which presumably impacts their pharmacokinetic profile and tumor exposure. Antica...

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Detalles Bibliográficos
Autores principales: Sen, Sajal, Perrin, Mark W., Sedgwick, Adam C., Lynch, Vincent M., Sessler, Jonathan L., Arambula, Jonathan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171490/
https://www.ncbi.nlm.nih.gov/pubmed/34163845
http://dx.doi.org/10.1039/d1sc01055g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171490/
https://www.ncbi.nlm.nih.gov/pubmed/34163845
http://dx.doi.org/10.1039/d1sc01055g

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