Cargando…

FOXO3a Protects against Kidney Injury in Type II Diabetic Nephropathy by Promoting Sirt6 Expression and Inhibiting Smad3 Acetylation

Diabetic nephropathy (DN) is the most common cause of end-stage renal disease. Although numerous reports have demonstrated a correlation between epithelial-mesenchymal transition (EMT) and renal fibrosis, how these processes lead to tubular dysfunction remains unclear. Here, we show that FOXO3a prot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xiaowei, Ji, Tingting, Li, Xiaoying, Qu, Xiaolei, Bai, Shoujun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172321/ https://www.ncbi.nlm.nih.gov/pubmed/34122724 http://dx.doi.org/10.1155/2021/5565761

Ejemplares similares

hsa-miR-199b-3p Prevents the Epithelial-Mesenchymal Transition and Dysfunction of the Renal Tubule by Regulating E-cadherin through Targeting KDM6A in Diabetic Nephropathy
por: Bai, Shoujun, et al.
Publicado: (2021)

Exosomal circ_DLGAP4 promotes diabetic kidney disease progression by sponging miR-143 and targeting ERBB3/NF-κB/MMP-2 axis
por: Bai, Shoujun, et al.
Publicado: (2020)

SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy
por: Zhao, Yanyan, et al.
Publicado: (2017)

EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer
por: Mahmud, Zimam, et al.
Publicado: (2019)

Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically?
por: Wang, Xianwang, et al.
Publicado: (2017)

Circ‐AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR‐296‐3p/E‐cadherin signals
por: Tang, Bo, et al.
Publicado: (2020)

Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions
por: Weinert, Brian T, et al.
Publicado: (2015)

Resolvin D1 Protects Podocytes in Adriamycin-Induced Nephropathy through Modulation of 14-3-3β Acetylation
por: Zhang, Xueming, et al.
Publicado: (2013)

Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3
por: Parodi-Rullán, Rebecca M., et al.
Publicado: (2018)

FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis
por: Li, Hailong, et al.
Publicado: (2023)

Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression
por: Cong, Lin, et al.
Publicado: (2023)

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression
por: Jacobs, Kristi Muldoon, et al.
Publicado: (2008)

SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3–FOXO1 signaling pathway
por: Zhang, Bin, et al.
Publicado: (2013)

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells
por: Zhong, Xiaolin, et al.
Publicado: (2020)

FoxO3 normalizes Smad3-induced arterial smooth muscle cell growth
por: Francisco, Jake T., et al.
Publicado: (2023)

LINC00052 ameliorates acute kidney injury by sponging miR-532-3p and activating the Wnt signaling pathway
por: Li, Xiaoying, et al.
Publicado: (2020)

FOXO3a-SIRT6 axis suppresses aerobic glycolysis in melanoma
por: Dong, Zhen, et al.
Publicado: (2020)

Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1
por: Li, Jingyuan, et al.
Publicado: (2016)

N(1)-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation
por: Zhang, Jingfan, et al.
Publicado: (2020)

Cooperative effects of SIRT1 and SIRT2 on APP acetylation
por: Li, Na, et al.
Publicado: (2023)

SIRT2 alleviated renal fibrosis by deacetylating SMAD2 and SMAD3 in renal tubular epithelial cells
por: Yang, Shu, et al.
Publicado: (2023)

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation
por: Aimjongjun, Sathid, et al.
Publicado: (2019)

Correction: Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1
por: Li, Jingyuan, et al.
Publicado: (2022)

Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3
por: Sun, Hai-Jian, et al.
Publicado: (2020)

Sirt1 protects neural stem cells from apoptosis by decreasing acetylation of histone 3K9
por: Jian, Chongdong, et al.
Publicado: (2018)

Chidamide Suppresses the Growth of Cholangiocarcinoma by Inhibiting HDAC3 and Promoting FOXO1 Acetylation
por: Li, Yongpan, et al.
Publicado: (2022)

Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy
por: Peng, Yonghan, et al.
Publicado: (2019)

Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy
por: You, Yong-Ke, et al.
Publicado: (2021)

Smad7 protects against chronic aristolochic acid nephropathy in mice
por: Dai, Xiao-Yu, et al.
Publicado: (2015)

SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis
por: Cao, Yang, et al.
Publicado: (2021)

Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy
por: Ono, Hiroyuki, et al.
Publicado: (2018)

miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation
por: Zhang, Mei, et al.
Publicado: (2017)

Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation
por: Kwon, Soon-Hyo, et al.
Publicado: (2017)

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy
por: Jiang, Mengjie, et al.
Publicado: (2019)

Retraction Note: Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy
por: Peng, Yonghan, et al.
Publicado: (2020)

Perampanel attenuates oxidative stress and pyroptosis following subarachnoid hemorrhage via the SIRT3/FOXO3α pathway
por: Yang, Hongqiao, et al.
Publicado: (2023)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

FOXO1 Negates the Cooperative Action of FOXL2(C134W) and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3
por: Belli, Martina, et al.
Publicado: (2019)

Aralia taibaiensis Protects against I/R-Induced Brain Cell Injury through the Akt/SIRT1/FOXO3a Pathway
por: Duan, Jialin, et al.
Publicado: (2019)

Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1
por: Jiang, Qingyuan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9clgqdeqogs7jfuk52v91rl7es