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PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation

It has not been well studied which cells and related mechanisms contribute to endochondral ossification. Here, we fate mapped the leptin receptor-expressing (LepR(+)) mesenchymal stem cells (MSCs) in different embryonic and adult extremities using Lepr-cre; tdTomato mice and investigated the underli...

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Detalles Bibliográficos
Autores principales: Yen, Yu-Ting, Chien, May, Wu, Pei-Yi, Hung, Shih-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172534/
https://www.ncbi.nlm.nih.gov/pubmed/34079065
http://dx.doi.org/10.1038/s42003-021-02175-1