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Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
Generating properly differentiated embryonic structures in vitro from pluripotent stem cells remains a challenge. Here we show that instruction of aggregates of mouse embryonic stem cells with an experimentally engineered morphogen signalling centre, that functions as an organizer, results in the de...
Autores principales: | Xu, Peng-Fei, Borges, Ricardo Moraes, Fillatre, Jonathan, de Oliveira-Melo, Maraysa, Cheng, Tao, Thisse, Bernard, Thisse, Christine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172561/ https://www.ncbi.nlm.nih.gov/pubmed/34078907 http://dx.doi.org/10.1038/s41467-021-23653-4 |
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