JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells

SARS-CoV-2 infection of human airway epithelium activates genetic programs leading to progressive hyperinflammation in COVID-19 patients. Here, we report on transcriptomes activated in primary airway cells by interferons and their suppression by Janus kinase (JAK) inhibitors. Deciphering the regulat...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hye Kyung, Jung, Olive, Hennighausen, Lothar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172581/
https://www.ncbi.nlm.nih.gov/pubmed/34079039
http://dx.doi.org/10.1038/s42003-021-02167-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172581/
https://www.ncbi.nlm.nih.gov/pubmed/34079039
http://dx.doi.org/10.1038/s42003-021-02167-1

Ejemplares similares