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JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells

SARS-CoV-2 infection of human airway epithelium activates genetic programs leading to progressive hyperinflammation in COVID-19 patients. Here, we report on transcriptomes activated in primary airway cells by interferons and their suppression by Janus kinase (JAK) inhibitors. Deciphering the regulat...

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Detalles Bibliográficos
Autores principales:	Lee, Hye Kyung, Jung, Olive, Hennighausen, Lothar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172581/ https://www.ncbi.nlm.nih.gov/pubmed/34079039 http://dx.doi.org/10.1038/s42003-021-02167-1

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