A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide

The SARS-CoV-2 nsp16/nsp10 enzyme complex modifies the 2′-OH of the first transcribed nucleotide of the viral mRNA by covalently attaching a methyl group to it. The 2′-O methylation of the first nucleotide converts the status of mRNA cap from Cap-0 to Cap-1, and thus, helps the virus evade immune su...

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Detalles Bibliográficos
Autores principales: Viswanathan, Thiruselvam, Misra, Anurag, Chan, Siu-Hong, Qi, Shan, Dai, Nan, Arya, Shailee, Martinez-Sobrido, Luis, Gupta, Yogesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172916/
https://www.ncbi.nlm.nih.gov/pubmed/34078893
http://dx.doi.org/10.1038/s41467-021-23594-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172916/
https://www.ncbi.nlm.nih.gov/pubmed/34078893
http://dx.doi.org/10.1038/s41467-021-23594-y

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