Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis

The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of protein entry into the ER lumen, blocks the in vitro translocati...

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Detalles Bibliográficos
Autores principales: Roboti, Peristera, O’Keefe, Sarah, Duah, Kwabena B., Shi, Wei Q., High, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173012/
https://www.ncbi.nlm.nih.gov/pubmed/34079010
http://dx.doi.org/10.1038/s41598-021-91107-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173012/
https://www.ncbi.nlm.nih.gov/pubmed/34079010
http://dx.doi.org/10.1038/s41598-021-91107-4

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